Semaglutide Dosage Chart: Complete Weekly Guide
How to use this chart: Most providers start at 0.25mg weekly for 4 weeks, then escalate based on tolerance. Compounded doses are in mg; convert to units using our dose calculator.
Standard Semaglutide Dose Escalation Chart
| Week | Dose (mg) | Phase | Notes |
|---|---|---|---|
| 1–4 | 0.25mg | Initiation | Starting dose — not therapeutic, builds tolerance |
| 5–8 | 0.5mg | Escalation | First therapeutic dose for most patients |
| 9–12 | 1.0mg | Escalation | Significant appetite suppression begins |
| 13–16 | 1.7mg | Escalation | Compounded dose — between Ozempic 1mg and 2mg |
| 17+ | 2.4mg | Maintenance | Wegovy max dose — most weight loss occurs here |
⚠ Important: Your prescriber may adjust this schedule based on your tolerance, side effects, and weight loss response. Never escalate faster than prescribed.
Compounded Semaglutide Dose Chart
Compounded semaglutide from 503B pharmacies is available in various vial concentrations. Common vial strengths:
| Vial Concentration | Common Doses Available | Use Calculator For |
|---|---|---|
| 2.5mg/mL | 0.25mg, 0.5mg, 1.0mg | Units to draw |
| 5mg/mL | 0.5mg, 1.0mg, 1.7mg, 2.4mg | Units to draw |
| 10mg/mL | 1.0mg, 2.0mg, 2.4mg | Units to draw |
💡 Use our GLP-1 dose calculator to convert any mg dose to the exact units to draw in your syringe based on your vial concentration.
Semaglutide Dose by Indication
| Indication | Starting Dose | Target Dose | Brand |
|---|---|---|---|
| Type 2 diabetes | 0.25mg/week | 0.5mg–1mg/week | Ozempic |
| Weight loss (obesity) | 0.25mg/week | 2.4mg/week | Wegovy |
| Cardiovascular risk reduction | 0.25mg/week | 2.4mg/week | Wegovy |
| Compounded (weight loss) | 0.25mg/week | 2.4mg/week | Various 503B |
When to Stay at Your Current Dose
Dose escalation is not always the right move. Stay at your current dose if:
- Nausea, vomiting, or diarrhea is still present from the last escalation
- You have not been at the current dose for the full 4 weeks
- Your prescriber has advised holding the dose
- You are losing weight steadily and tolerating the current dose well
See also: Semaglutide Dosing Schedule · Side Effects Timeline
Related Guides on GLPDosing.com
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