Can Semaglutide Be Refrigerated?

Refrigeration Requirements for Semaglutide

Whether you are using brand-name Ozempic, Wegovy, or compounded semaglutide from a 503B pharmacy, refrigeration is the standard storage requirement. The peptide structure of semaglutide degrades when exposed to heat or light over time.

Where in the Refrigerator Should You Store It?

Placement inside the refrigerator matters more than most people realize:

• Middle shelf: Best location — consistent temperature, away from the cooling element
• Door shelves: Avoid — temperature fluctuates every time the door opens
• Back of fridge: Avoid — can get too cold near the cooling coil and risk partial freezing
• Crisper drawer: Acceptable if temperature is stable

Compounded Semaglutide Storage Notes

Compounded semaglutide vials from 503B pharmacies often contain bacteriostatic water as the diluent. Once reconstituted, storage rules apply immediately. Always follow the specific guidance printed on your pharmacy label, as beyond-use dates vary by formulation.

• Most compounded vials: refrigerate, use within 28–56 days of reconstitution
• Keep the rubber stopper clean — wipe with alcohol before each draw
• Do not shake the vial — swirl gently if needed

What Happens If Semaglutide Gets Warm?

Short excursions above 77°F are concerning but not automatically catastrophic. See our full guide on what happens if semaglutide gets warm for a decision framework on whether to use or discard a warm vial.

Traveling With Semaglutide

Travel introduces the most common storage challenges. See our traveling with semaglutide guide for TSA rules, insulated carry options, and how to handle hotel stays without a mini-fridge.