What Happens If Semaglutide Gets Warm?

Temperature Tolerance: What the Data Shows

Pharmaceutical semaglutide (Ozempic, Wegovy) is rated stable at room temperature up to 77°F for up to 56 days after first use. Compounded semaglutide may have a shorter tolerance window — check your pharmacy label.

Signs a Vial May Be Compromised

Visual inspection alone cannot confirm potency, but these are red flags:

• Solution appears cloudy or discolored (should be clear and colorless)
• Visible particles floating in the solution
• Unusual smell when drawing up
• Reduced effectiveness at your normal dose (possible sign of degradation)

What to Do After Heat Exposure

1. Return the vial to the refrigerator immediately
2. Inspect visually — look for cloudiness or particles
3. Note how long it was warm and at what approximate temperature
4. If under 77°F and less than 8 hours: likely acceptable to continue
5. If over 77°F or longer than 8 hours: contact your prescriber or pharmacy before using

Preventing Heat Exposure

The most common heat exposure scenarios and how to prevent them:

• Forgot to put it in the fridge after delivery: Most pharmacy shipments use cold packs rated for 24–48 hours. Check your packaging insert.
• Left in a hot car: Never leave medication in a car in warm weather — even a brief stop can spike car interior temps above 100°F.
• Traveling: Use an insulated medication travel case with a cooling insert. See our traveling with semaglutide guide.