Semaglutide Cost Comparison: Ozempic vs Wegovy vs Compounded
Full Cost Comparison Table
| Option | List Price/Month | With Insurance | With Savings Program |
|---|---|---|---|
| Ozempic (0.5mg–2mg) | ~$935 | $25–$150 (diabetes coverage) | $25/month (NovoCare card) |
| Wegovy (2.4mg) | ~$1,349 | Rare — most plans exclude | Up to $500 off (insured only) |
| Compounded semaglutide (low dose) | $150–$250 | Not covered | No savings programs |
| Compounded semaglutide (high dose) | $300–$500 | Not covered | No savings programs |
| Rybelsus (oral semaglutide) | ~$935 | Sometimes (diabetes) | NovoCare savings available |
Who Pays What
With commercial insurance + diabetes diagnosis
Ozempic is most likely to be covered. With the NovoCare savings card, eligible patients pay as little as $25/month. This is the most affordable brand-name pathway.
With commercial insurance, weight loss only
Wegovy coverage is expanding slowly but most plans still exclude it. Out-of-pocket cost is $1,349/month unless your plan specifically covers anti-obesity medication.
Medicare or Medicaid
Medicare Part D now covers anti-obesity medications under certain conditions. Check your specific plan — coverage varies significantly.
No insurance / cash pay
Compounded semaglutide from a licensed 503B pharmacy via telehealth is typically the most accessible option at $150–$500/month depending on dose and provider.
Annual Cost Comparison
| Option | Monthly | Annual |
|---|---|---|
| Wegovy (no insurance) | ~$1,349 | ~$16,200 |
| Ozempic (no insurance) | ~$935 | ~$11,200 |
| Compounded (mid-dose) | ~$300 | ~$3,600 |
| Compounded (low dose) | ~$200 | ~$2,400 |
Is Compounded Semaglutide as Effective?
Compounded semaglutide contains the same active molecule as Ozempic and Wegovy when sourced from a licensed 503B facility. The difference is the delivery format (vial vs pen) and the lack of FDA approval for the compounded product specifically. Clinical outcomes data for compounded formulations specifically is limited, but the active ingredient is identical.
See also: Cheapest Semaglutide Providers · Best Tirzepatide Providers · Semaglutide Dosage Chart
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